An Attenuated Adenovirus, ONYX-015, As Mouthwash Therapy for Premalignant Oral Dysplasia

PURPOSE: Dysplastic lesions of the oral epithelium are known precursors of oral cancer. A significant proportion of oral dysplastic lesions have functional defects in p53 response pathways. The ONYX-015 adenovirus is selectively cytotoxic to cells carrying defects in p53-dependent signaling pathways...

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Udgivet i:J Clin Oncol
Main Authors: Rudin, Charles M., Cohen, Ezra E.W., Papadimitrakopoulou, Vassiliki A., Silverman, Sol, Recant, Wendy, El-Naggar, Adel K., Stenson, Kirsten, Lippman, Scott M., Hong, Waun Ki, Vokes, Everett E.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4523388/
https://ncbi.nlm.nih.gov/pubmed/14597742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2003.03.544
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