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Chromosomal directionality of DNA mismatch repair in Escherichia coli

Defects in DNA mismatch repair (MMR) result in elevated mutagenesis and in cancer predisposition. This disease burden arises because MMR is required to correct errors made in the copying of DNA. MMR is bidirectional at the level of DNA strand polarity as it operates equally well in the 5′ to 3′ and...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hasan, A. M. Mahedi, Leach, David R. F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522816/
https://ncbi.nlm.nih.gov/pubmed/26170312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505370112
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