Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

Members of the AAA family of ATPases assemble into hexameric double rings and perform vital functions, yet their molecular mechanisms remain poorly understood. Here, we report structures of the Pex1/Pex6 complex; mutations in these proteins frequently cause peroxisomal diseases. The structures were...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Blok, Neil B., Tan, Dongyan, Wang, Ray Yu-Ruei, Penczek, Pawel A., Baker, David, DiMaio, Frank, Rapoport, Tom A., Walz, Thomas
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2015
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522808/
https://ncbi.nlm.nih.gov/pubmed/26170309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1500257112
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