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Matrix cross-linking–mediated mechanotransduction promotes posttraumatic osteoarthritis
Osteoarthritis (OA) is characterized by impairment of the load-bearing function of articular cartilage. OA cartilage matrix undergoes extensive biophysical remodeling characterized by decreased compliance. In this study, we elucidate the mechanistic origin of matrix remodeling and the downstream mec...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522801/ https://ncbi.nlm.nih.gov/pubmed/26170306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505700112 |
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