Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis.

Ligand induced activation of the beta-receptor for platelet-derived growth factor (PDGF) leads to activation of Src family tyrosine kinases. We have explored the possibility that the receptor itself is a substrate for Src. We show that Tyr934 in the kinase domain of the PDGF receptor is phosphorylat...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Hansen, K, Johnell, M, Siegbahn, A, Rorsman, C, Engström, U, Wernstedt, C, Heldin, C H, Rönnstrand, L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452274/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8895575/
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