Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

The immunosuppressant, rapamycin, inhibits cell growth by interfering with the function of a novel kinase, termed mammalian target of rapamycin (mTOR). The putative catalytic domain of mTOR is similar to those of mammalian and yeast phosphatidylinositol (PI) 3-kinases. This study demonstrates that m...

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Библиографические подробности

Опубликовано в::	EMBO J
Главные авторы:	Brunn, G J, Williams, J, Sabers, C, Wiederrecht, G, Lawrence, J C, Abraham, R T
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Publishing Group 1996
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452270/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8895571/
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