Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on peritoneal carcinomatosis

BACKGROUND: Suppressor of cytokine signaling1 (SOCS1) is a negative regulator of various cytokines. Recently, it was investigated as a therapeutic target in various cancers. However, the observed antitumour effects of SOCS1 cannot not be fully explained without taking inhibition of proliferation sig...

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Pubblicato in:Br J Cancer
Autori principali: Natatsuka, Rie, Takahashi, Tsuyoshi, Serada, Satoshi, Fujimoto, Minoru, Ookawara, Tomohiro, Nishida, Toshirou, Hara, Hisashi, Nishigaki, Takahiko, Harada, Emi, Murakami, Takashi, Miyazaki, Yasuhiro, Makino, Tomoki, Kurokawa, Yukinori, Yamasaki, Makoto, Miyata, Hiroshi, Nakajima, Kiyokazu, Takiguchi, Shuji, Kishimoto, Tadamitsu, Mori, Masaki, Doki, Yuichiro, Naka, Tetsuji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522636/
https://ncbi.nlm.nih.gov/pubmed/26180928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.229
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