Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue

CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1(–/–)), C57/BL6J mice fed a high-fat (HF) diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, followed by hyperinsulinemia, insulin resistance, and visceral...

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Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Lester, Sumona G., Russo, Lucia, Ghanem, Simona S., Khuder, Saja S., DeAngelis, Anthony M., Esakov, Emily L., Bowman, Thomas A., Heinrich, Garrett, Al-Share, Qusai Y., McInerney, Marcia F., Philbrick, William M., Najjar, Sonia M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522571/
https://ncbi.nlm.nih.gov/pubmed/26284027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2015.00116
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