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A method for determining δ-aminolevulinic acid synthase activity in homogenized cells and tissues

OBJECTIVE: In mammalian cells the rate-limiting step in heme biosynthesis is the formation of δ-aminolevulinic acid (ALA). The reaction intermediates, porphyrins and iron and the final product, heme can be highly cytotoxic if allowed to accumulate. The importance of maintaining the levels of metabol...

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Publicat a:Clin Biochem
Autors principals: Bergonia, Hector A., Franklin, Michael R., Kushner, James P., Phillips, John D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522353/
https://ncbi.nlm.nih.gov/pubmed/25959086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clinbiochem.2015.04.023
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