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DNA repair defects and genome instability in Hutchinson-Gilford Progeria Syndrome
The integrity of the nuclear lamina has emerged as an important factor in the maintenance of genome stability. In particular, mutations in the LMNA gene, encoding A-type lamins (lamin A/C), alter nuclear morphology and function, and cause genomic instability. LMNA gene mutations are associated with...
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| Publicado no: | Curr Opin Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522337/ https://ncbi.nlm.nih.gov/pubmed/26079711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2015.05.007 |
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