Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

The block of terminal differentiation is a prominent feature of acute promyelocytic leukemia (APL) and its release by retinoic acid correlates with disease remission. Expression of the APL-specific PML/RARalpha fusion protein in hematopoietic precursor cell lines blocks terminal differentiation, sug...

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Detalles Bibliográficos
Publicado en:EMBO J
Autores principales: Grignani, F, Testa, U, Rogaia, D, Ferrucci, P F, Samoggia, P, Pinto, A, Aldinucci, D, Gelmetti, V, Fagioli, M, Alcalay, M, Seeler, J, Nicoletti, I, Peschle, C, Pelicci, P G
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452232/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8890168/
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