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HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.

The murine MHC class II molecule H2-O is expressed in B-cells and in thymic epithelium but the human equivalent, HLA-DO (DO), has not been detected, though the corresponding genes, HLA-DNA and HLA-DOB, are well known. Here we show DO to be a lysosomal resident in B-cells. Surprisingly, DO forms stab...

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Published in:EMBO J
Main Authors: Liljedahl, M, Kuwana, T, Fung-Leung, W P, Jackson, M R, Peterson, P A, Karlsson, L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452218/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8890155/
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