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HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.
The murine MHC class II molecule H2-O is expressed in B-cells and in thymic epithelium but the human equivalent, HLA-DO (DO), has not been detected, though the corresponding genes, HLA-DNA and HLA-DOB, are well known. Here we show DO to be a lysosomal resident in B-cells. Surprisingly, DO forms stab...
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| Опубликовано в: : | EMBO J |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
1996
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452218/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8890155/ |
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