Aspirin Action in Endothelial Cells: Different Patterns of Response Between Chemokine CX3CL1/CX3CR1 and TNF-α/TNFR1 Signaling Pathways

PURPOSE: TNF-α induces fractalkine (CX3CL1) and its receptor CX3CR1 in endothelial cells through NF-қB activation. NF-қB inhibitors may reduce the expression of CX3CL1, and modulation of the CX3CL1/CX3CR1 signaling was proposed as a new target for aspirin. We examined the effects of aspirin on CX3CL...

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Bibliographic Details
Published in:Cardiovasc Drugs Ther
Main Authors: Szukiewicz, Dariusz, Wojciechowska, Malgorzata, Bilska, Anna, Stangret, Aleksandra, Szewczyk, Grzegorz, Mittal, Tarun Kumar, Watroba, Mateusz, Kochanowski, Jan
Format: Artigo
Language:Inglês
Published: Springer US 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522030/
https://ncbi.nlm.nih.gov/pubmed/25959742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-015-6589-2
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