Regulation of SREBPs by Sphingomyelin in Adipocytes via a Caveolin and Ras-ERK-MAPK-CREB Signaling Pathway

Sterol response element binding protein (SREBP) is a key transcription factor in insulin and glucose metabolism. We previously demonstrated that elevated levels of membrane sphingomyelin (SM) were related to peroxisome proliferator–activated receptor-γ (PPARγ), which is a known target gene of SREBP-...

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Publicat a:PLoS One
Autors principals: Makdissy, Nehman, Haddad, Katia, Mouawad, Charbel, Popa, Iuliana, Younsi, Mohamed, Valet, Philippe, Brunaud, Laurent, Ziegler, Olivier, Quilliot, Didier
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521865/
https://ncbi.nlm.nih.gov/pubmed/26230734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133181
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