KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia

BACKGROUND: Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-currents, play a key role in neuro...

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Vydáno v:Mol Pain
Hlavní autoři: Abd-Elsayed, Alaa A, Ikeda, Ryo, Jia, Zhanfeng, Ling, Jennifer, Zuo, Xiaozhuo, Li, Min, Gu, Jianguo G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521366/
https://ncbi.nlm.nih.gov/pubmed/26227020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0048-8
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