KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia

BACKGROUND: Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-currents, play a key role in neuro...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pain
Main Authors: Abd-Elsayed, Alaa A, Ikeda, Ryo, Jia, Zhanfeng, Ling, Jennifer, Zuo, Xiaozhuo, Li, Min, Gu, Jianguo G
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521366/
https://ncbi.nlm.nih.gov/pubmed/26227020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12990-015-0048-8
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