IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells

Interleukin-17 (IL-17)-producing γδ T (γδ17) cells have been implicated in inflammatory diseases, but the underlying pathogenic mechanisms remain unclear. Here, we show that both CD4(+) and γδ17 cells are required for the development of autoimmune arthritis in IL-1 receptor antagonist (IL-1Ra)-defic...

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Udgivet i:Nat Commun
Main Authors: Akitsu, Aoi, Ishigame, Harumichi, Kakuta, Shigeru, Chung, Soo-hyun, Ikeda, Satoshi, Shimizu, Kenji, Kubo, Sachiko, Liu, Yang, Umemura, Masayuki, Matsuzaki, Goro, Yoshikai, Yasunobu, Saijo, Shinobu, Iwakura, Yoichiro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4521288/
https://ncbi.nlm.nih.gov/pubmed/26108163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8464
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