Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping

Induction of fetal hemoglobin (HbF) production in adult erythrocytes can reduce the severity of sickle cell disease and β-thalassemia. Transcription of β-globin genes is regulated by the distant locus control region (LCR), which is brought into direct gene contact by the LDB1/GATA-1/TAL1/LMO2-contai...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Blood
Main Authors: Krivega, Ivan, Byrnes, Colleen, de Vasconcellos, Jaira F., Lee, Y. Terry, Kaushal, Megha, Dean, Ann, Miller, Jeffery L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2015
Teme:
Red Cells, Iron, and Erythropoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520881/
https://ncbi.nlm.nih.gov/pubmed/25979948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-629972
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