Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.

Expression of human growth hormone (hGH) was targeted to growth hormone-releasing (GRF) neurons in the hypothalamus of transgenic rats. This induced dominant dwarfism by local feedback inhibition of GRF. One line, bearing a single copy of a GRF-hGH transgene, has been characterized in detail, and ha...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Flavell, D M, Wells, T, Wells, S E, Carmignac, D F, Thomas, G B, Robinson, I C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452083/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8670892/
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