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Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons.

Expression of human growth hormone (hGH) was targeted to growth hormone-releasing (GRF) neurons in the hypothalamus of transgenic rats. This induced dominant dwarfism by local feedback inhibition of GRF. One line, bearing a single copy of a GRF-hGH transgene, has been characterized in detail, and ha...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Flavell, D M, Wells, T, Wells, S E, Carmignac, D F, Thomas, G B, Robinson, I C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1996
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC452083/
https://ncbi.nlm.nih.gov/pubmed/8670892
Tagiau: Ychwanegu Tag
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