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Locating herpesvirus Bcl-2 homologs in the specificity landscape of anti-apoptotic Bcl-2 proteins

Viral homologs of the anti-apoptotic Bcl-2 proteins are highly diverged from their mammalian counterparts, yet they perform overlapping functions by binding and inhibiting BH3 motif-containing proteins. We investigated the BH3 binding properties of the herpesvirus Bcl-2 homologs KSBcl-2, BHRF1, and...

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Pubblicato in:J Mol Biol
Autori principali: Foight, Glenna Wink, Keating, Amy E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520770/
https://ncbi.nlm.nih.gov/pubmed/26009469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.015
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