Proteasomes play an essential role in thymocyte apoptosis.

Cell death in many different organisms requires the activation of proteolytic cascades involving cytosolic proteases. Here we describe a novel requirement in thymocyte cell death for the 20S proteasome, a highly conserved multicatalytic protease found in all eukaryotes. Specific inhibitors of protea...

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Autori principali: Grimm, L M, Goldberg, A L, Poirier, G G, Schwartz, L M, Osborne, B A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1996
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC452071/
https://ncbi.nlm.nih.gov/pubmed/8670888
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