Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling

Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice leads to impaired synaptic plasticity, suggestive of a role...

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Publicat a:EMBO Mol Med
Autors principals: D'Andrea, Ivana, Fardella, Valentina, Fardella, Stefania, Pallante, Fabio, Ghigo, Alessandra, Iacobucci, Roberta, Maffei, Angelo, Hirsch, Emilio, Lembo, Giuseppe, Carnevale, Daniela
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520656/
https://ncbi.nlm.nih.gov/pubmed/25882071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404697
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