Lack of kinase-independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling

Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice leads to impaired synaptic plasticity, suggestive of a role...

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Pubblicato in:EMBO Mol Med
Autori principali: D'Andrea, Ivana, Fardella, Valentina, Fardella, Stefania, Pallante, Fabio, Ghigo, Alessandra, Iacobucci, Roberta, Maffei, Angelo, Hirsch, Emilio, Lembo, Giuseppe, Carnevale, Daniela
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520656/
https://ncbi.nlm.nih.gov/pubmed/25882071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404697
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