The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

Increased osteoclast-mediated bone resorption is characteristic of osteoporosis, malignant bone disease and inflammatory arthritis. Targeted deletion of Sirtuin1 (Sirt1), a key player in aging and metabolism, in osteoclasts results in increased osteoclast-mediated bone resorption in vivo, making it...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gurt, Irina, Artsi, Hanna, Cohen-Kfir, Einav, Hamdani, Gilad, Ben-Shalom, Gal, Feinstein, Ben, El-Haj, Madi, Dresner-Pollak, Rivka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520518/
https://ncbi.nlm.nih.gov/pubmed/26226624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134391
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