Human Pol ε-Dependent Replication Errors and the Influence of Mismatch Repair on Their Correction

Mutations in human DNA Polymerase (Pol) ε, one of three eukaryotic Pols required for DNA replication, have recently been found associated with an ultramutator phenotype in tumors from somatic colorectal and endometrial cancers and in a familial colorectal cancer. Possibly, Pol ε mutations reduce the...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Agbor, Anderson Ayuk, Göksenin, A. Yasemin, LeCompte, Kimberly G., Hans, Samuel H., Pursell, Zachary F.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520434/
https://ncbi.nlm.nih.gov/pubmed/24051051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.08.012
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