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Human Pol ε-Dependent Replication Errors and the Influence of Mismatch Repair on Their Correction
Mutations in human DNA Polymerase (Pol) ε, one of three eukaryotic Pols required for DNA replication, have recently been found associated with an ultramutator phenotype in tumors from somatic colorectal and endometrial cancers and in a familial colorectal cancer. Possibly, Pol ε mutations reduce the...
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| Udgivet i: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520434/ https://ncbi.nlm.nih.gov/pubmed/24051051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.08.012 |
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