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Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs
Sensory neurons expressing Mas-related G protein coupled receptors (Mrgprs) mediate histamine-independent itch. We show that the cysteine protease cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. In contrast to its activation of conventional protease-activated recepto...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520244/ https://ncbi.nlm.nih.gov/pubmed/26216096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8864 |
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