Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

Sensory neurons expressing Mas-related G protein coupled receptors (Mrgprs) mediate histamine-independent itch. We show that the cysteine protease cathepsin S activates MrgprC11 and evokes receptor-dependent scratching in mice. In contrast to its activation of conventional protease-activated recepto...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Reddy, Vemuri B., Sun, Shuohao, Azimi, Ehsan, Elmariah, Sarina B., Dong, Xinzhong, Lerner, Ethan A.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520244/
https://ncbi.nlm.nih.gov/pubmed/26216096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8864
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