Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis.

The p53 tumor suppressor limits cellular proliferation by inducing either G1 arrest or apoptosis, depending on the cellular context. To determine if these pathways are mechanistically distinct, we have examined the effects of different p53 mutants in p53 null primary mouse embryo fibroblasts. We cho...

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Detaylı Bibliyografya
Asıl Yazarlar: Attardi, L D, Lowe, S W, Brugarolas, J, Jacks, T
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1996
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC452024/
https://ncbi.nlm.nih.gov/pubmed/8758936
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