A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia

BACKGROUND: A variety of genetic variants lead to abnormal human spermatogenesis. The ubiquitin-conjugating enzyme E2B (UBE2B) plays a significant role in spermatogenesis as Ube2b-knockout male mice are infertile. METHODS: In this study, we sequenced the exon and promoter region of UBE2B in 776 pati...

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Detalhes bibliográficos
Publicado no:Reprod Biol Endocrinol
Main Authors: Mou, Lisha, Zhang, Qiang, Diao, Ruiying, Cai, Zhiming, Gui, Yaoting
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520152/
https://ncbi.nlm.nih.gov/pubmed/26223869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-015-0074-4
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