AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle

BACKGROUND: Insulin resistance triggered by excess fat is a key pathogenic factor that promotes type 2 diabetes. Understanding molecular mechanisms of insulin resistance may lead to the identification of a novel therapeutic target for type 2 diabetes. AMPD1, an isoform of AMP deaminase (AMPD), is su...

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Bibliographic Details
Published in:BMC Endocr Disord
Main Authors: Tandelilin, Andreas AK, Hirase, Tetsuaki, Hudoyo, Athanasius W, Cheng, Jidong, Toyama, Keiko, Morisaki, Hiroko, Morisaki, Takayuki
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520000/
https://ncbi.nlm.nih.gov/pubmed/25887856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12902-015-0010-9
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