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Brain feminization requires active repression of masculinization via DNA methylation

The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a perinatal sensitive period. It has been assumed that the undifferentiated brain is masculinized by direct induction of transcription by ligand-activated nuclear steroid receptors. We found t...

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Bibliografische gegevens
Gepubliceerd in:Nat Neurosci
Hoofdauteurs: Nugent, Bridget M., Wright, Christopher L., Shetty, Amol C., Hodes, Georgia E., Lenz, Kathryn M., Mahurkar, Anup, Russo, Scott J., Devine, Scott E., McCarthy, Margaret M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4519828/
https://ncbi.nlm.nih.gov/pubmed/25821913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3988
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