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Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective technique

BACKGROUND: According to current clinical guidelines mutational analysis for KRAS and NRAS is recommended prior to EGFR-directed therapy of colorectal cancer (CRC) in the metastatic setting. Therefore, reliable, fast, sensitive and cost-effective methods for routine tissue based molecular diagnostic...

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Detalhes bibliográficos
Publicado no:Diagn Pathol
Main Authors: Kriegsmann, Mark, Arens, Norbert, Endris, Volker, Weichert, Wilko, Kriegsmann, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518505/
https://ncbi.nlm.nih.gov/pubmed/26220423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-015-0364-3
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