Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

Immune thrombocytopenia (ITP) is a common bleeding disorder caused primarily by autoantibodies against platelet GPIIbIIIa and/or the GPIb complex. Current theory suggests that antibody-mediated platelet destruction occurs in the spleen, via macrophages through Fc–FcγR interactions. However, we and o...

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Udgivet i:Nat Commun
Main Authors: Li, June, van der Wal, Dianne E., Zhu, Guangheng, Xu, Miao, Yougbare, Issaka, Ma, Li, Vadasz, Brian, Carrim, Naadiya, Grozovsky, Renata, Ruan, Min, Zhu, Lingyan, Zeng, Qingshu, Tao, Lili, Zhai, Zhi-min, Peng, Jun, Hou, Ming, Leytin, Valery, Freedman, John, Hoffmeister, Karin M., Ni, Heyu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518313/
https://ncbi.nlm.nih.gov/pubmed/26185093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8737
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