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Locking GTPases covalently in their functional states

GTPases act as key regulators of many cellular processes by switching between active (GTP-bound) and inactive (GDP-bound) states. In many cases, understanding their mode of action has been aided by artificially stabilizing one of these states either by designing mutant proteins or by complexation wi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wiegandt, David, Vieweg, Sophie, Hofmann, Frank, Koch, Daniel, Li, Fu, Wu, Yao-Wen, Itzen, Aymelt, Müller, Matthias P., Goody, Roger S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518245/
https://ncbi.nlm.nih.gov/pubmed/26178622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8773
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