The Lysophosphatidylinositol Receptor GPR55 Modulates Pain Perception in the Periaqueductal Gray

Emerging evidence indicates the involvement of GPR55 and its proposed endogenous ligand, lysophosphatidylinositol (LPI), in nociception, yet their role in central pain processing has not been explored. Using Ca(2+) imaging, we show here that LPI elicits concentration-dependent and GPR55-mediated inc...

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Udgivet i:Mol Pharmacol
Main Authors: Deliu, Elena, Sperow, Margaret, Console-Bram, Linda, Carter, Rhonda L., Tilley, Douglas G., Kalamarides, Daniel J., Kirby, Lynn G., Brailoiu, G. Cristina, Brailoiu, Eugen, Benamar, Khalid, Abood, Mary E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518086/
https://ncbi.nlm.nih.gov/pubmed/25972448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099333
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