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Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 Subunit
Alterations in expression patterns of α4β2 nicotinic acetylcholine receptors have been demonstrated to alter cholinergic neurotransmission and are implicated in neurologic disorders, including autism, nicotine addiction, Alzheimer’s disease, and Parkinson’s disease. Positive allosteric modulators (P...
Enregistré dans:
| Publié dans: | J Pharmacol Exp Ther |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4518072/ https://ncbi.nlm.nih.gov/pubmed/26025967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.223933 |
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