The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex

Hyperactivation of the mechanistic target of rapamycin (mTOR) kinase, as a result of loss-of-function mutations in tuberous sclerosis complex 1 (TSC1) or TSC2 genes, causes protein synthesis dysregulation, increased cell size, and aberrant neuronal connectivity. Dysregulated synthesis of synaptic pr...

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發表在:J Neurosci
Main Authors: Nie, Duyu, Chen, Zehua, Ebrahimi-Fakhari, Darius, Di Nardo, Alessia, Julich, Kristina, Robson, Victoria K., Cheng, Yung-Chih, Woolf, Clifford J., Heiman, Myriam, Sahin, Mustafa
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2015
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518051/
https://ncbi.nlm.nih.gov/pubmed/26224859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4796-14.2015
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