Crystal Structure of a Thermostable Alanine Racemase from Thermoanaerobacter tengcongensis MB4 Reveals the Role of Gln360 in Substrate Selection

Pyridoxal 5’-phosphate (PLP) dependent alanine racemase catalyzes racemization of L-Ala to D-Ala, a key component of the peptidoglycan network in bacterial cell wall. It has been extensively studied as an important antimicrobial drug target due to its restriction in eukaryotes. However, many markete...

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Bibliographic Details
Published in:PLoS One
Main Authors: Sun, Xiaoliang, He, Guangzheng, Wang, Xiaoyan, Xu, Shujing, Ju, Jiansong, Xu, Xiaoling
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517790/
https://ncbi.nlm.nih.gov/pubmed/26218070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133516
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