Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes

OBJECTIVE: Immune suppression during critical illness predisposes to serious infections. We sought to determine the mechanisms regulating tolerance and cross-tolerance to common pro-inflammatory danger signals in a model that recapitulates the intact in vivo immune response. MATERIALS AND METHODS: F...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Julian, Mark W., Strange, Heather R., Ballinger, Megan N., Hotchkiss, Richard S., Papenfuss, Tracey L., Crouser, Elliott D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517781/
https://ncbi.nlm.nih.gov/pubmed/26218271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132921
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