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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
BACKGROUND: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. METHODS: To...
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| Опубликовано в: : | Genome Med |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517488/ https://ncbi.nlm.nih.gov/pubmed/26221185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0180-0 |
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