The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells

BACKGROUND: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. METHODS: To...

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Vydáno v:Genome Med
Hlavní autoři: Liefke, Robert, Windhof-Jaidhauser, Indra M., Gaedcke, Jochen, Salinas-Riester, Gabriela, Wu, Feizhen, Ghadimi, Michael, Dango, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517488/
https://ncbi.nlm.nih.gov/pubmed/26221185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0180-0
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