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The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells
BACKGROUND: The oxidative DNA demethylase ALKBH3 targets single-stranded DNA (ssDNA) in order to perform DNA alkylation damage repair. ALKBH3 becomes upregulated during tumorigenesis and is necessary for proliferation. However, the underlying molecular mechanism remains to be understood. METHODS: To...
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| 出版年: | Genome Med |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4517488/ https://ncbi.nlm.nih.gov/pubmed/26221185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0180-0 |
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