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The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis

Notch signaling controls a wide range of cell fate decisions during development and disease via synergistic interactions with other signaling pathways. Here, through a genome-wide genetic screen in Drosophila, we uncover a highly complex Notch-dependent genetic circuitry that profoundly affects prol...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Ho, Diana M, Pallavi, SK, Artavanis-Tsakonas, Spyros
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517436/
https://ncbi.nlm.nih.gov/pubmed/26222204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05996
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