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Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

Our understanding of cancer has greatly advanced since Nordling [Nordling CO (1953) Br J Cancer 7(1):68–72] and Armitage and Doll [Armitage P, Doll R (1954) Br J Cancer 8(1):1–12] put forth the multistage model of carcinogenesis. However, a number of observations remain poorly understood from the st...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Rozhok, Andrii I., DeGregori, James
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517250/
https://ncbi.nlm.nih.gov/pubmed/26195756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501713112
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