Suppression of conformational heterogeneity at a protein–protein interface

Staphylococcal protein A (SpA) is an important virulence factor from Staphylococcus aureus responsible for the bacterium’s evasion of the host immune system. SpA includes five small three-helix–bundle domains that can each bind with high affinity to many host proteins such as antibodies. The interac...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Deis, Lindsay N., Wu, Qinglin, Wang, You, Qi, Yang, Daniels, Kyle G., Zhou, Pei, Oas, Terrence G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517213/
https://ncbi.nlm.nih.gov/pubmed/26157136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424724112
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