Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia

Spontaneous organ hemorrhage is the major complication in thrombocytopenia with a potential fatal outcome. However, the exact mechanisms regulating vascular integrity are still unknown. Here, we demonstrate that neutrophils recruited to inflammatory sites are the cellular culprits inducing thrombocy...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Hillgruber, Carina, Pöppelmann, Birgit, Weishaupt, Carsten, Steingräber, Annika Kathrin, Wessel, Florian, Berdel, Wolfgang E., Gessner, J. Engelbert, Ho-Tin-Noé, Benoît, Vestweber, Dietmar, Goerge, Tobias
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516803/
https://ncbi.nlm.nih.gov/pubmed/26169941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20142076
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