Synthesis, F-18 Radiolabeling, and MicroPET Evaluation of 3-(2,4-Dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as Ligands of the Corticotropin-Releasing Factor Type-1 (CRF(1)) Receptor

A series of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines were synthesized and evaluated as potential positron emission tomography (PET) tracers for the corticotropin-releasing factor type-1 (CRF(1)) receptor. Compounds 27,28,29, and 30 all displayed high...

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Udgivet i:Bioorg Med Chem
Main Authors: Stehouwer, Jeffrey S., Birnbaum, Matthew S., Voll, Ronald J., Owens, Michael J., Plott, Susan J., Bourke, Chase H., Wassef, Michael A., Kilts, Clinton D., Goodman, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4516694/
https://ncbi.nlm.nih.gov/pubmed/26145817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.06.036
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