A carregar...
Synthesis, Binding Affinity, Radiolabeling, and MicroPET Evaluation of 4-(2-Substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as Ligands for Brain Corticotropin-Releasing Factor Type-1 (CRF(1)) Receptors
Compounds 1–14 were synthesized in a search for high-affinity CRF(1) receptor ligands that could be radiolabeled with (11)C or (18)F for use as positron emission tomography (PET) radiotracers. Derivatives of 2 were developed which contained amide N-fluoroalkyl substituents. Compounds [(18)F]24 and [...
Na minha lista:
| Publicado no: | Bioorg Med Chem Lett |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4628894/ https://ncbi.nlm.nih.gov/pubmed/26456805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.010 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|